Palabras clave
Cáncer de pulmón
Análisis de supervivencia
Enriquecimiento de vías biológicas
Biomarcadores
Cómo citar
Resumen
Introducción: Las diferencias biológicas relacionadas con el sexo pueden contribuir a la heterogeneidad molecular del LUAD, incluidas las variaciones en la expresión de miARN.
Objetivo: Identificar miARN asociados al LUAD según el sexo y evaluar su asociación con la supervivencia de los pacientes y las vías biológicas enriquecidas.
Métodos: Se analizaron por separado datos de expresión de miARN y datos clínicos del The Cancer Genome Atlas (TCGA) para hombres y mujeres. Se realizaron análisis de expresión diferencial, supervivencia y enriquecimiento de vías biológicas.
Resultados: Se identificaron 130 miARN diferencialmente expresados en hombres y 208 en mujeres. Dos miARN se asociaron con la supervivencia en el grupo masculino y ocho en el grupo femenino. El análisis de enriquecimiento reveló perfiles funcionales distintos entre ambos grupos.
Conclusión: Estos hallazgos exploratorios indican diferencias relacionadas con el sexo en los patrones de expresión de miARN y en sus asociaciones con la supervivencia y las vías biológicas en el LUAD, proporcionando una base para futuras investigaciones sobre su posible relevancia pronóstica.
Citas
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Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Derechos de autor 2026 Bethina da Rocha Camargo, Bruna Caroline Silva Previato, Felipe de Almeida Camargo (Autor); Carlo Antônio de Freitas Lüders (Tradutor); Vanessa das Graças Pereira de Souza, Patricia Pintor dos Reis, Rogerio Antonio de Oliveira (Autor)