Palavras-chave
Câncer de pulmão
Análise de sobrevivência
Enriquecimento de vias biológicas
Biomarcadores
Como Citar
Resumo
Introdução: Diferenças biológicas relacionadas ao sexo podem contribuir para a heterogeneidade molecular do LUAD, incluindo variações na expressão de miRNAs.
Objetivo: Identificar miRNAs associados ao LUAD de acordo com o sexo e avaliar suas associações com a sobrevida e vias biológicas enriquecidas.
Métodos: Dados de expressão de miRNAs e dados clínicos do The Cancer Genome Atlas foram analisados separadamente para homens e mulheres. Foram realizadas análises de expressão diferencial, sobrevida e enriquecimento de vias biológicas.
Resultados: Foram identificados 130 miRNAs diferencialmente expressos em homens e 208 em mulheres. Dois miRNAs foram associados à sobrevida no grupo masculino e oito no feminino. A análise de enriquecimento revelou perfis funcionais distintos entre os grupos.
Conclusão: Os achados exploratórios indicam diferenças relacionadas ao sexo nos perfis de miRNAs e em suas associações com a sobrevida e vias biológicas no LUAD, fornecendo subsídios para futuras investigações sobre seu potencial prognóstico.
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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2026 Bethina da Rocha Camargo, Bruna Caroline Silva Previato, Felipe de Almeida Camargo (Autor); Carlo Antônio de Freitas Lüders (Tradutor); Vanessa das Graças Pereira de Souza, Patricia Pintor dos Reis, Rogerio Antonio de Oliveira (Autor)